Furthermore, we demonstrated that blocking ETRs on B cells from infected mice suppressed the activation of splenic B cells both in vivo and in vitro, and the fibrosis was attenuated after treated with endothelin receptor antagonists, suggesting the endothelin receptor antagonists had a beneficial effect on schistosome-induced hepatic fibrosis through preventing the development of splenic B cells characterized by IL-10 secretion and the Treg cell-inducing capacity. Here, IL10 is linked to Hepatic fibrosis.