In the current study, we provide evidence for a functional role of ETRs in human and murine hepatic fibrosis with S. japonicum. Our data indicate that the up-regulation of ETAR and ETBR is crucial for the progression of hepatic fibrosis induced by schistosome infection, and ETRs are predominantly expressed on splenic B cells in spleen tissues. The gene discussed is EDNRB; the disease is Hepatic fibrosis.