Compared with control human spleen, the elevated levels of ETAR (2.6-fold) and ETBR (4.2-fold) were predominantly expressed on splenic B cells in spleen tissues of patients with schistosome-induced hepatic fibrosis (Fig 2K), while they were scarce on endothelial cells of the splenic sinus (S2 Fig). Here, EDNRB is linked to Hepatic fibrosis.