BRINP3 and depressive symptom measurement: The strongest signals (p-value < 5×10−9) were identified at SNP clusters in the intergenic regions near BRINP3, URB2, GRIA1 and LOC400682 and in the intronic regions at MGAT5, C3orf20, and LINC01861, where BRINP3 was associated with BMI measurement [25, 26, 31], depression [47], and rheumatoid arthritis [48], and GRIA1 was associated with schizophrenia [33, 49, 50] and circadian rhythm [51].