Two other newly identified genotypes of B-ALL, DUX4-rearranged (with overexpression of DUX4 and transcriptional deregulation of ERG) and ETV6-RUNX1like (with gene expression profile similar to that of ETV6-RUNX1-positive ALL and coexisting ETV6 and IKZF1 alterations), appeared to have favorable prognosis in retrospect studies [14,20,21]. The gene discussed is ERG; the disease is acute lymphoblastic leukemia.