KMT2A and leukemia: KMT2A-rearranged, Philadelphia chromosome-positive and ZNF384-rearranged leukemias are the most common genotypes among B-myeloid leukemia, and biallelic WT1 alterations are common in the T-myeloid subtype, which shares genomic features such as RAS and JAK–STAT pathway mutations with early T cell precursor ALL [55].