In the CI group, the most frequent tumor biopsy ISUP grade was 2 (32%, 17/53) and only 53% (28/53) of the patients had high-risk disease according to D’Amico score, while in the PSMA group, around half of the patients (48%, 25/52) presented ISUP grade 4 tumors and 84.5% (44/52) had high-risk disease. The gene discussed is FOLH1; the disease is neoplasm.