MFN2 and Charcot-Marie-Tooth disease type 2A1: To further evaluate the relevance of the MFN2 T105M mouse to human CMT2A, dorsal root ganglion (DRG) sensory neurons were isolated and placed in culture, the MFN2 T105M transgene induced with Adeno-Cre, and neurons assayed for the mitochondrial pathologies delineated in reprogrammed CMT2A patient motor neurons (vide supra).