NLRC4 and shigellosis: Our new shigellosis model will finally allow the field to leverage the outstanding genetic and immunological tools and reagents in the mouse to address fundamental questions about the immune response to Shigella. Our finding that NAIP–NLRC4 inflammasome-deficient mice clear the attenuated Shigella icsA strain, derivatives of which are currently deployed in human vaccine trials (Collins et al., 2008; Coster et al., 1999; Ranallo et al., 2014), speaks to the readiness of our model to support testing and development of Shigella therapeutics.