However, the susceptibility of B6 NAIP–NLRC4-deficient (but CASP11+) mice, as well as the resistance of Casp1/11–/– mice, suggest that these inflammasomes are not strictly redundant and that NAIP–NLRC4 alone is sufficient to confer resistance to shigellosis in mice. The gene discussed is NAIP; the disease is shigellosis.