MAPT and Alzheimer disease: This notion has been substantiated by neuropathological findings in AD patients, including widespread propagation of AD pathological hallmarks, such as amyloid-beta (Aβ) and tau deposits, damage and loss of synapses, and large corticocortical connections in the brain (Corder et al., 2000; Delbeucket al., 2003; Uylings and de Brabander, 2002).