In summary, we have provided evidence that TLR4 participates in the rapid uptake of fetuin‐A by tumor cells and that inhibition of TLR4 activation by a specific inhibitor of the receptor attenuates the fetuin‐A mediated physiological events in tumor cells such as rapid adhesion, cell spreading, invasion, and growth on the substrata. The gene discussed is TLR4; the disease is neoplasm.