Using CEN‐tools, we isolated such genes (Fig 2B) and revealed a subnetwork consisting of a number of transcription factors (TFs) that are known to control tissue differentiation into a specific lineage such as SOX10 in skin (Harris et al, 2013), PAX8 in ovary, kidney and endometrium ((Grote et al, 2006; Cheung et al, 2011; Tong et al, 2011), and MYCN in neuroblastoma (Huang & Weiss, 2013). The gene discussed is PAX8; the disease is neuroblastoma.