The role of IGF1R in mediating acquired resistance of BRAF mutant melanoma cells to BRAF inhibitors is well‐studied (Villanueva et al, 2010; Corcoran et al, 2011); however, the role of IGF1R in NRAS‐mutant melanoma is not completely understood and further work will be required to establish the precise manner in which NRAS‐mutant melanoma cell lines are dependent on IGF1R. Additionally, the identification of genes encoding proteins such as ITGAV, RHOA and RAC1 suggest a potential role of cellular components controlling cell adhesion and cytoskeletal organisation in NRAS‐mutant melanoma. This evidence concerns the gene RAC1 and melanoma.