Similarly, our study, for the first time, implied that ITGB1, ITGB4, ITGB5 and ITGB6 overexpressions were significantly associated with up‐regulation of focal adhesion signalling pathway, suggesting the potential role of ITGB1, ITGB4, ITGB5 and ITGB6 in focal adhesion signalling pathway in PC. The gene discussed is ITGB4; the disease is pachyonychia congenita.