These programs, however, lead to the detection of a high number of inconclusive cases, also referred to as Cystic Fibrosis Screen Positive, Inconclusive Diagnosis (CFSPID) in Europe or CFTR-related metabolic syndrome (CRMS) in the US, compared to the number of CF cases [1,7]. Here, CFTR is linked to CFTR-related metabolic syndrome/CF screen positive, inconclusive diagnosis.