Interesting, in these patients, there a patient who was diagnosed as Congenital adrenal hyperplasia with salt-wasting (SW) and simple virializing (SV) and high 17ohp screened by MS/MS many times in 2014–2019 but the result of the Sanger sequencing and MLPA of CYP21A2 gene shows that the patient just c.293-13A>G heterozygous mutation carrier inherited from his father. Here, CYP21A2 is linked to congenital adrenal hyperplasia.