TSHR and cyclic hematopoiesis: PA8 gene heterozygous mutations are associated with Permanent CH(PCH), TSHR heterozygous mutations are associated with TSH elevation, TSHR with DUOX2/TG heterozygous mutations are associated with CH, most single or multiple DUOX2 mutations are associated with Transient CH (TCH) or TSH elevation and multiple DUOX2 mutation sites are associated with PCH.