The hotspot mutation in SLC22A5 gene of PCD were c.51C>G (25.3%), c.1400C>G (23.0%) and c.760C>T(13.8%); in PAH gene of HPA were c.728G>A (22.2%) and c.721C>T(14.8%); in ACADS gene of SCAD was c.1031A>G (38.9%); and in SLC25A13 gene of NICCD was c.851_854delGTAT (50.0%). This evidence concerns the gene SLC25A13 and pulmonary arterial hypertension.