Although all NBS programs in the US currently screen for the most common forms of SCD (HbSS, Hb SC, and Hb S/β thalassemia), there is wide variability across states with respect to screening, reporting, and referral of other hemoglobinopathies identified in the course of screening for the core panel conditions. The gene discussed is GSTM1; the disease is hemoglobinopathy.