Among these, 109 cases were directed to the clinical unit: 1 methylmalonic aciduria with homocystinuria (CblC), 1 methylmalonic aciduria type B (CblB), 3 methylmalonil-CoA mutase (MUT) deficiencies, 3 propionic acidemias and, 3 cystathionine-β-synthase (CBS) deficiencies were genetically diagnosed, besides 1 case of suspected MUT/CblA or CblB. The gene discussed is CBLB; the disease is propionic acidemia.