IFNG and type 1 diabetes mellitus: Similarly, feeding NOD mice with wheat flour for 72 days shows the same effect with a decrease in the levels of IFN-γ (a proinflammatory cytokine involved in the autoimmune pathogenesis of T1D) and an increase in the levels of IL-10 (an anti-inflammatory cytokine potentially implicated in hindering T1D development) (127).