Studies have suggested that NR2F2, also known as chicken ovalbumin upstream promoter transcriptional factor II (COUP-TFII), serves as a major regulator to control angiogenesis within the tumor microenvironment and tumor lymphangiogenesis through cooperation with VEGF/VEGFR signaling, although the specific details need to be further elucidated (100, 101). Here, VEGFA is linked to neoplasm.