SYK and lymphangioleiomyomatosis: This study identified a Syk-dependent signaling inducing VEGF-D expression in peripheral blood mononuclear cells by monocyte chemoattractant protein (MCP)-1, which was elevated via signal transducer and activator of transcription (Stat3) signaling downstream of the mTORC1 signaling (56), demonstrating the strong therapeutic potential of Syk in LAM treatment.