This study identified a Syk-dependent signaling inducing VEGF-D expression in peripheral blood mononuclear cells by monocyte chemoattractant protein (MCP)-1, which was elevated via signal transducer and activator of transcription (Stat3) signaling downstream of the mTORC1 signaling (56), demonstrating the strong therapeutic potential of Syk in LAM treatment. Here, VEGFD is linked to lymphangioleiomyomatosis.