TSC1 and lymphangioleiomyomatosis: A study has found upregulated phosphorylation of Src on Tyr416 in lung tissues of LAM patients compared with normal tissues, and enhanced activation of Src-kinase signaling pathway resulted from autophagy inhibition was observed in vitro studies in which Src inhibition of saracatinib reduced the epithelial–mesenchymal transition (EMT) which is promoted by overexpression of Src in TSC-deficient cells (50).