CLOCK and atherosclerosis: Clock (Circadian Locomotor Output Cycles Kaput) and Bmal1 [Brain and Muscle ARNT (aryl hydrocarbon receptor nuclear translocator) -Like 1], two major circadian clock genes, play important regulatory role in atherogenesis, expression of Bmal1 and Clock decreased in patients with atherosclerosis (Winter and Soehnlein, 2018; Man et al., 2020).