Apart from a significant increase in SOD2 activity in HD cells upon neural differentiation (Figure 6D), which may partially counterbalance the enhanced production of mitochondrial O2⋅–, no other significant differences were detected in SODs levels (including acetyl-SOD2 at Lys68) (2A-B) or total SOD activity (not shown). The gene discussed is SOD2; the disease is Huntington disease.