Particularly, Arf6 role on melanoma progression and tumorigenesis is mediated by Ras/RAF/MEK/ERK signaling pathway, which activates Rac1, leading to cytoskeleton remodeling and the formation of invadopodia (Tague et al., 2004; Muralidharan-Chari et al., 2009). Here, ARF6 is linked to melanoma.