EPHB4 and melanoma: On the one hand, RAB27A induces melanoma invasion through the production of pro-invasive exosomes carrying out protein cargos such as EPHB4, Glypican1, and BMP 1, previously described as a pivotal protein for melanoma cell motility (Yang et al., 2006; Aikawa et al., 2008; Peinado et al., 2012; Guo et al., 2019, 2020).