Enhanced apoptosis in NAFLD hepatocytes correlates with activation of caspases (Feldstein et al., 2003; Ferreira et al., 2011) and both FAS -an apoptosis signal transduction factor- and its ligand -FAS-L- were found upregulated in NAFLD (Feldstein et al., 2003; Li C. P. et al., 2014; Alkhouri et al., 2015). Here, FAS is linked to metabolic dysfunction-associated steatotic liver disease.