Tgfbr2 silencing in forebrain-derived neural progenitors and neural cells impedes EC migration and sprouting, decreases vessel density and branching via altered secretion of pro- and anti-angiogenic factors, thereby leading to intracerebral hemorrhage in the telencephalon (Hellbach et al., 2014). The gene discussed is TGFBR2; the disease is intracerebral hemorrhage.