Approximately, 20% of all CCMs are Familial CCMs which present autosomal dominant inheritance with loss-of-function germline mutations in any one of the following three genes: CCM1/KRIT1, CCM2/malcavernin, or CCM3/PDCD10 (Zafar et al., 2019). The gene discussed is CCM2; the disease is cerebrocostomandibular syndrome.