Ramsay et al. reported the aberrant expression of METTL14 in AML cells and its involvement in the regulation of the expression of MYB and MYC through m6A-based post-transcriptional regulation, indicating the critical role of METTL14 in the self-renewal of LSCs/LICs and development of AML (Ramsay and Gonda, 2008). The gene discussed is MYB; the disease is acute myeloid leukemia.