Fore example, miR-143 can increase the sensitivity of glioma cells to apoptotic death upon temozolomide treatment owing to its targeting of N-Ras, and miR-124 can similarly enhance the chemosensitivity of glioma cells via its regulation of both N-Ras and R-Ras (Shi et al., 2014; Wang et al., 2014). Here, RRAS is linked to central nervous system cancer.