Altered PINK1/parkin signaling in dopaminergic neurons has been strictly associated to the pathogenesis of PD (Truban et al., 2017; Lin et al., 2019; Noda et al., 2020), and defective mitophagy is an additional hallmark of AD, FTD and ALS diseases (Cai and Jeong, 2020; Xie et al., 2020). Here, PRKN is linked to Parkinson disease.