Failure in CMA has been detected in PD to dismantle abnormal alpha-synuclein aggregates (a favorite CMA substrate), but alsoin AD, TD and HD to remove excessive tau protein, TAR DNA-binding protein 43 (TDP-43) and huntingtin protein, respectively (Martinez-Vicente et al., 2010; Cuervo and Wong, 2014; Wu et al., 2015; Tripathi et al., 2019). Here, TARDBP is linked to thanatophoric dysplasia.