As for PD mouse model triggered by methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MTP), resveratrol ameliorated locomotor activity and the number of dopaminergic neurons in the substantia nigra pars compacta, promoting Sirtuin 1/LC3II and reducing p62/SQSTM (Guo et al., 2016). Here, SIRT1 is linked to Parkinson disease.