Flavonoids like quercetin coupled to nanoparticles, silibinin and wogonin have been successfully used in vitro in SH-SY5Y neurons, and in vivo in rodent and human AD, where they induced autophagy by ULK1/mTOR, beclin 1 production and clearing amyloid substance (Wang D. et al., 2014; Ashrafizadeh et al., 2019b; Liu et al., 2019; Zhang et al., 2020). This evidence concerns the gene BECN1 and Alzheimer disease.