ACTA1 and adenocarcinoma: Infiltrative adenocarcinomas of the colon showed a desmoplastic reaction in the submucosa (Figure 6A) and serosa (Figure 6B), in which numerous elongated stromal cells around the neoplastic glands presented αSMA expression (myofibroblastic phenotype) (Figures 6A,B) and were negative for anti-CD34 (Figure 6C).