This list covered all HSP genes (SPGs) known at the time of study including 65 HSP genes (SPG1 – SPG80; SPGs with defined chromosomal loci but unknown genes could not be analyzed), 30 ALS-related genes, 18 SMA-related genes and 55 spasticity-related genes. The gene discussed is SMN1; the disease is amyotrophic lateral sclerosis.