SMN1 and amyotrophic lateral sclerosis: Using RNA-Sequencing (RNA-Seq) analyses we here compared the transcript expression profiles of more than 160 MND-related genes including all spastic paraplegia genes (SPGs), SMA genes and ALS genes known so far in biosamples of two independent healthy individuals including (i) PBMCs and (ii) fibroblasts as primary cells, (iii) lymphoblasts and (iv) iPSCs as immortalized cell lines as well as, and (v) iPSC-derived cortical projection neurons representing a cell type predominantly affected in HSP and ALS.