HDGFL2 and infection: The concurrent flow of human and parasite populations potentially increases the diversity of strains with different drug-resistant profiles (33), genome deletion that prevents the diagnostic capacity (i.e., HRP-2 deletion) (34), and infectivity efficiency, defined as the “ability of a given Plasmodium strain to establish an infection in an Anopheles mosquito species and undergo development until the mosquito has sporozoites in its salivary glands”(32).