HIF1A and tuberculosis: This mechanistic analysis was supported by in vivo studies showing that whole-body HIF-1α−/− mice are more susceptible to TB (Braverman et al., 2016), and this was later enhanced by two studies showing that myeloid-specific conditional HIF-1α knockout mice are also more susceptible to TB (Osada-Oka et al., 2019; Resende et al., 2020).