Interestingly, decelerated glycolysis was observed in Mtb infected hMDMs after 24 h of infection (Cumming et al., 2018), miRNA-21 has been reported to limit glycolysis in Mtb infected macrophages by repressing PFK-M expression (Hackett et al., 2020) and increased host hydrogen sulfide generation also depressed glycolysis in the Mtb infected macrophages (Rahman et al., 2020). Here, PFKM is linked to infection.