Lots of studies indicated that in the early stage of sepsis induced by different pathogens, circulating T lymphocytes were decreased to varying degrees in number and function of them, manifested as expression of typical T cell exhaustion markers, programmed death-1 (PD-1) or its ligand (PD-L1) (Gogos et al., 2010; Spec et al., 2016). The gene discussed is CD274; the disease is Sepsis.