DAXX and infection: Despite the ability of the pp71 tegument protein to stimulate viral gene expression by antagonizing Daxx, pp71 fails to traffic to the nucleus and degrade Daxx in cells that support latency (Saffert et al., 2010), a restriction that is overcome by higher multiplicities of infection or virions with high levels of pp71 (Woodhall et al., 2006; Chaturvedi et al., 2020).