Epidermal growth factor receptor (EGFR) is not mutated but overexpressed in MPM, leading to deregulation of EGFR signaling and aberrant activation of downstream pathways such as RAS/RAF/MAPK and PI3K/AKT/mTOR, which in turn promotes cell proliferation, tumor invasiveness and angiogenesis (60). This evidence concerns the gene EGFR and neoplasm.