TP53 and neoplasm: Apart from the loss of TP53 tumor suppressor functions and increased expression of survival signals, overexpression of pro-survival B-cell lymphoma 2 (BCL-2) family proteins (BCL-2, BCL-XL, MCL-1, BCL-W, BCL-B, BFL-1) that dampen apoptosis by sequestering pro-apoptotic activators (BAX, BIM, PUMA) is another pivotal strategy to circumvent apoptosis (86).