Merlin exerts tumor-suppressor function by translocating to the nucleus, where it promotes the degradation of two paralogous transcriptional co-activators, Yes-associated protein (YAP) and WWTR1 (WW domain containing transcription regulator 1)/transcriptional coactivator with PDZ-binding motif (TAZ) via the E3 ubiquitin ligase CRL4DCAF1 (37). This evidence concerns the gene WWTR1 and neoplasm.