In human HCC, it was reported that SRSF3 expression was either downregulated or the protein was mislocalized (105), whereas Wang found a significant increasing expression of SRSF3 in human HCC tumors (30, 95), which emerged progressive upregulation from a normal liver to a cirrhosis/fibrosis liver, and ultimately HCC (30). This evidence concerns the gene SRSF3 and hepatocellular carcinoma.