SRSF3 and neoplasm: Moreover, SRSF3 knockout also induced the nudE neurodevelopment protein 1 (NDE1) gene to a mutually exclusive exon 9' taking the place of the terminal exon 9, resulting in the production of isoform-specific function of NDE1 (NDE1-E9) in mitotic spindle formation that is important for tumor cell growth (23).