SRSF3, as a potential diagnostic and prognostic biomarker, is upregulated in multiple types of human cancer, including breast cancer (85–88), ovarian cancer (26, 89), retinoblastoma (90, 91), head and neck cell squamous (62, 79, 92), glioblastoma (GBM) (23), gastric cancer (36), colorectal cancer (CRC) (33, 36, 93), cervical cancer (94), and hepatocellular carcinoma (HCC) (30, 95). This evidence concerns the gene SRSF3 and hepatocellular carcinoma.