The top 10 mutated genes in 467 melanoma patients are TTN (72%), MUC16 (67%), BRAF (51%), DNAH5 (49%), PCLO (44%), LRP1B (38%), ADGRV1 (35%), RP1 (33%), ANK3 (32%), DNAH7 (32%) (Figure 1A). The gene discussed is LRP1B; the disease is melanoma.