CD4 and melanoma: Cox analysis implied that higher levels of CD4+ T cell (HR = 20.246, P = 0.049), macrophage (HR = 12.960, P = 0.033), BIRC5 expression (HR = 1.321, P = 0.001) and lower levels of neutrophil (HR < 0.001, P = 0.020) were risk factors for prognosis in melanoma patients (Table 4).