The multifactor model with a minimum prediction error (TBA 0.7648) and CVC (10/10) was NAT2_rs1799929-NQ01_rs2811566-CYP2E1_rs1803867-alcohol consumption by the mother before pregnancy (ACMBP)-medicine consumption by the mother before pregnancy (MCMBP)-PSFBC suggesting that these factors jointly contributed to the etiology of ALL (Figure 4, Table 5). The gene discussed is CYP2E1; the disease is acute lymphoblastic leukemia.