CEACAM8 and gastric cancer: High-level TANs in GC patients have been shown to be associated with disease progression and poor clinical outcome (12), but in Epstein–Barr virus-associated gastric carcinoma with abundant lymphocytic interstitium, a high density of CD66b-positive TANs is associated with intestinal-type histology and low frequency of LNM (25), and the presence of neutrophil infiltration in the corpus was closely related to the development of metachronous gastric cancer after ESD (26).