Figure 5 shows the morphological characteristics of mature and immature CAFs in tumor tissues. The mature CAFs were associated with TANs in all SM tumors (r = 0.180, P = 0.046) (Table 3) and in SM2 tumors (r = 0.215, P = 0.034) (Table 4), but they had no correlation in SM1 tumors (Supplementary Table S7). Importantly, the mature CAFs were significantly related to LNM in SM2 tumors (P = 0.004) (Supplementary Table S8). Here, TBX1 is linked to systemic mastocytosis.