Total: 63%, n = 399  Hypothyroidism (11%, n = 69)  Fatigue (8%, n = 50)  Pruritus (7%, n = 46)  Rash (7%, n=46)  Alanine aminotransferase increased (7%, n = 45)  Pneumonitis (7%, n = 43)  Decreased appetite (6%, n = 40)  Hyperthyroidism (6%, n = 37). The gene discussed is GPT; the disease is hypothyroidism.