CXCR4, namely, C-X-C chemokine receptor type 4, a cognate receptor for CXCL12 (also known as stromal-derived factor 1), can mediate glycolysis programming through the CXCL12/CXCR4/mTOR signal axis, promoting the “Warburg” effect of AML cells (55). Here, CXCL12 is linked to acute myeloid leukemia.