These selected genes were separated into the risky type (STC1, CLDN9, NT5E, CXCR4), with HR>1 related to poorer prognosis, and the protective type (EFNA3, ZBTB7A, NUP50), with HR <1 related to better prognosis (Table 2), among which five genes (STC1, CLDN9, ZBTB7A, NT5E, CXCR4) were also considered as independent prognostic factors of GC. The gene discussed is EFNA3; the disease is gastric cancer.