These selected genes were separated into the risky type (STC1, CLDN9, NT5E, CXCR4), with HR>1 related to poorer prognosis, and the protective type (EFNA3, ZBTB7A, NUP50), with HR <1 related to better prognosis (Table 2), among which five genes (STC1, CLDN9, ZBTB7A, NT5E, CXCR4) were also considered as independent prognostic factors of GC. This evidence concerns the gene ZBTB7A and gastric cancer.