While studies have investigated the role of RAB31 in the cancer cells of hepatic cancer, breast cancer, pancreatic cancer, gastric cancer, and glioblastoma (10–12, 34, 35), we described the functional role of RAB31 in colon cancer-derived CAFs because its expression in the tumor stroma but not cancer cells predicted poor survival. Here, RAB31 is linked to familial pancreatic carcinoma.