The study has confirmed that the gene ACOX2 (acyl-CoA oxidase 2) in subpathway 00120_11 and GLDC (glycine decarboxylase), SHMT 1/2 (serine hydroxymethyltransferase 1/2) of 00630_1 are closely related to IDH mutation in GBM (47–49). This evidence concerns the gene IDH2 and glioblastoma.