Adipocyte cells in addition to have a function in storage, it also has an ability to secrete various proteins protein in the form of enzymes, transcription factors and carrier molecules.5,6 Proteins such as sirtuin-1, peroxisome proliferator-activated receptor γ (PPAR γ), and GLUT-4 have an important role in the development of obesity and type 2 diabetes mellitus.7 Sirtuin-1 is a master regulator enzyme found in adipocyte cells and plays a role in the body’s energy balance. This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.