Given the enormous variety of prescribed drugs in clinical trials for the treatment of NAFLD, multi-drug combination studies and many not-investigated drugs in head-to-head trials, we have aimed to evaluate the effectiveness of most commonly used medications on reducing liver transaminases (alanine aminotransferase (ALT), aspartate amino transferase (AST), body mass index (BMI), NAFLD activity score (NAS) and steatosis in patients with NAFLD in a systematic review and network meta-analysis. This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.