SLC6A3 and Parkinson disease: α-Syn also has a role in DAT activity, it is involved in the downregulation of DAT by clathrin-mediated endocytosis, lowering its cell surface levels, this was tested by Ksios et al. in cultured cells and in mouse brains mimicking Parkinson’s disease when transgenic A532 α-Syn was used, results of which showed decreased uptake of dopamine from the synaptosome decreased recycling, and loss of dopamine eventually [36].