Statins have been shown to have a protective effect on NAFLD/NASH through inhibition of small GTPases (family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate) such as ras homologous family member A (RhoA) and rat sarcoma protein (Ras) by decreasing the isoprenoid levels. Here, RHOA is linked to metabolic dysfunction-associated steatotic liver disease.