NLRP3 and metabolic dysfunction-associated steatohepatitis: Several animal studies have proved cholesterol to be lipotoxic and promote NASH development by forming cholesterol crystals in steatotic hepatocytes, which activates nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasomes and Kupffer cells (KCs) enlargement forming “crown-like structures” (CLSs), and resulting into chronic inflammation and fibrosis [23].