For example, miR-101 suppresses cell proliferation and facilitates cell apoptosis by inhibiting mTOR in Saos-2 cells [16], promotes Bcl2-regulated apoptosis by RLIP76 in prostate cancer cells [17], represses tumour growth and migration by ROCK1 in osteosarcoma cells [18]. This evidence concerns the gene BCL2 and Familial prostate cancer.