In lymphocytes, a host regulatory element named paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1), which is proposed as a proto-oncogene in lymphomas, regulating antigen receptor-related NF-κB activation by induction of IKK complex activation and cleavage of inhibitory factors of canonical NF-κB (A20 and RelB) [99]. The gene discussed is NFKB1; the disease is lymphoma.