S. aureus can secrete a wide range of virulence factors, among which staphylococcal serine protease-like proteins (Spls) have been identified as bacterial allergens and inducers of allergic asthma in C57BL/6J mice by activating the IL-33/ST2 signaling axis (3, 4). The gene discussed is IL1RL1; the disease is allergic asthma.