It has been demonstrated that MPs in RA patients express TNF-α on their surface (69), Barbati et al., showed that MPs can induce the activation of asparaginase 3 and TNF-related apoptosis-inducing ligand (TRAIL) and TNF receptor, three independent signals that promote endothelial cell apoptosis, which can lead to the formation of atherosclerosis (62, 70). This evidence concerns the gene TNFSF10 and rheumatoid arthritis.