Similarily, whereas IL-10 plasma concentrations remained at a high level throughout the observation period, peripheral tissue concentrations of this anti-inflammatory cytokine increased in all organs studied after 4 h of sepsis duration and began to decline in liver tissue after 8 h of sepsis (mean of 1,335 vs. 467 pg/mg protein, p < 0.01, after 5.5 and 8 h of sepsis duration, respectively) (Figure 8D). This evidence concerns the gene IL10 and Sepsis.