Whereas, plasma concentrations for TNF (mean concentration of 6,142 pg/ml), IL-6 (31,000 pg/ml), and IL-10 (2,322 pg/ml) were already very high after 4 h of sepsis duration and subsequently remained elevated, IL-1β plasma concentrations increased only after 5.5 h of sepsis initiation to levels comparable to the other cytokines (mean concentrations of 1,273 pg/ml after 8 h). The gene discussed is TNF; the disease is Sepsis.