TNF and Neonatal sepsis: These data support therefore the conclusion that (GENT + PTX) treatment of E. coli-infected neonatal mice significantly diminished the TNF-to-IL-10 concentration ratios in plasma and all organ tissues except the liver as compared to GENT alone and/or saline controls, thus indicating a shift toward an anti-inflammatory milieu through addition of PTX to antimicrobial therapy in murine neonatal sepsis.