IL6 and Sepsis: Additionally, GENT-treated female mice had 4-fold higher IL-6 in lung, whereas (GENT + PTX)-treated male mice presented with higher IL-6 concentrations in lung (~2.5-fold), spleen (2.3-fold), and brain tissues (6-fold) at 5.5 h after sepsis initiation compared to their female counterparts (Table 1).