Despite the fact that TGF-β transcription remains unaffected in WT, IL-10 might play a role favoring non-pathogenic heart remodeling, since it has been shown to promote M1-to-M2 macrophage polarization and hyaluronan degradation in a mouse model of myocardial infarction (34). This evidence concerns the gene TGFB1 and myocardial infarction.