However, we observed a decreased frequency of CD39+ cells among CD8+ and γδ+ T cells in individuals diagnosed with IBD compared to healthy donors (γδ+: HD 78.36% vs IBD 57.65%, p = 0.0049; CD8+: HD 59.37% vs IBD 47.45%, p = 0.0325) (Figure 2A). The gene discussed is CD8A; the disease is inflammatory bowel disease.