Remarkably, γδ+ Trm displayed significantly lower frequencies of IL-17A+ and IFN-γ+ cells compared to their non-Trm counterparts in both healthy donors and IBD patients (healthy: γδ+ IL17A+: 0.709% vs 4.051%, p = 0.0078; γδ+ IFN-γ+: 37.95% vs 83.85%, p = 0.002; IBD: γδ+ IL17A+: 1.14% vs 4.799%, p = 0.0469; γδ+ IFN-γ+: 38.37% vs 76.83%, p = 0.0078) (Figure 7B). Here, IL17A is linked to inflammatory bowel disease.